What You Need to Know Ahead of Grey’s Anatomy’s 20th Season

When Grey’s Anatomy began airing as a mid-season pickup in March 2005, no one could have predicted how quickly the show would rise to national and international acclaim. Audiences immediately enjoyed watching the five main interns navigate their first year in medicine, and the show became known for its dramatic storylines, incredible soundtrack, and big speeches. With a cast of mostly unknown actors, Patrick Dempsey as Dr. Derek Shepherd was the initial draw for many viewers, but it was his relationship with Meredith Grey (Ellen Pompeo) and the dynamic friendships (and rivalries!) that kept people coming back.With the end of the WGA and SAG-AFTRA strikes, Grey’s Anatomy began filming its 20th season in November 2023, with a premiere date set for March 2024. Though expected to be considerably shorter than previous seasons, the upcoming season will be the show’s first full season without the title character, given Pompeo’s departure at the end of Season 19. Other characters, both regular and recurring, will return to the medical drama and its spin-off show, Station 19, which is now in its 7th season. Now the longest-running scripted primetime television medical drama ever and the second longest-running scripted primetime drama led by a woman, Season 20 of Grey’s Anatomy is destined to be one for the history books.The surgical interns at Grey-Sloan Memorial Hospital (initially called Seattle Grace) are central to the success of Grey’s Anatomy. M.A.G.I.C. became residents in Season 4, which is when viewers met new interns like Lexie Grey (Chyler Leigh), Meredith’s half-sister on her father’s side, and Sadie Harris (Melissa George), Meredith’s old friend from college. The Season 4 and 5 interns were responsible for the “Intern Cabal,” which began in Season 5, Episode 7, “Rise Up,” when several interns began performing procedures on themselves. The secret procedures nearly ended in tragedy in Season 5, Episode 9, “In the Midnight Hour,” when the interns decide to perform a “routine” appendectomy on Sadie, which turns out to be not so routine. Interns that came later include Jo Wilson (Camilla Luddington), who arrived in Season 9, Episode 1, “Going, Going, Gone,” and remains on the show as an OB/GYN resident, as well as Andrew DeLuca (Giacomo Gianniotti), who arrived in Season 11, Episode 23, “Time Stops,” dated Meredith throughout Season 15, and died in Season 17, Episode 7, “Helplessly Hoping,” after being stabbed. In Season 14, Episode 1, “Break Down the House,” viewers met Levi Schmitt (Jake Borelli) and Taryn Helm (Jaicy Elliot), who were both displaced when the residency program was shut down at the end of Season 18 but became co-chief residents in Season 19, Episode 18, “Ready to Run.”

When Grey’s Anatomy began airing as a mid-season pickup in March 2005, no one could have predicted how quickly the show would rise to national and international acclaim. Audiences immediately enjoyed watching the five main interns navigate their first year in medicine, and the show became known for its dramatic storylines, incredible soundtrack, and big speeches. With a cast of mostly unknown actors, Patrick Dempsey as Dr. Derek Shepherd was the initial draw for many viewers, but it was his relationship with Meredith Grey (Ellen Pompeo) and the dynamic friendships (and rivalries!) that kept people coming back.

With the end of the WGA and SAG-AFTRA strikes, Grey’s Anatomy began filming its 20th season in November 2023, with a premiere date set for March 2024. Though expected to be considerably shorter than previous seasons, the upcoming season will be the show’s first full season without the title character, given Pompeo’s departure at the end of Season 19. Other characters, both regular and recurring, will return to the medical drama and its spin-off show, Station 19, which is now in its 7th season. Now the longest-running scripted primetime television medical drama ever and the second longest-running scripted primetime drama led by a woman, Season 20 of Grey’s Anatomy is destined to be one for the history books.

The surgical interns at Grey-Sloan Memorial Hospital (initially called Seattle Grace) are central to the success of Grey’s Anatomy. M.A.G.I.C. became residents in Season 4, which is when viewers met new interns like Lexie Grey (Chyler Leigh), Meredith’s half-sister on her father’s side, and Sadie Harris (Melissa George), Meredith’s old friend from college. The Season 4 and 5 interns were responsible for the “Intern Cabal,” which began in Season 5, Episode 7, “Rise Up,” when several interns began performing procedures on themselves. The secret procedures nearly ended in tragedy in Season 5, Episode 9, “In the Midnight Hour,” when the interns decide to perform a “routine” appendectomy on Sadie, which turns out to be not so routine. Interns that came later include Jo Wilson (Camilla Luddington), who arrived in Season 9, Episode 1, “Going, Going, Gone,” and remains on the show as an OB/GYN resident, as well as Andrew DeLuca (Giacomo Gianniotti), who arrived in Season 11, Episode 23, “Time Stops,” dated Meredith throughout Season 15, and died in Season 17, Episode 7, “Helplessly Hoping,” after being stabbed. In Season 14, Episode 1, “Break Down the House,” viewers met Levi Schmitt (Jake Borelli) and Taryn Helm (Jaicy Elliot), who were both displaced when the residency program was shut down at the end of Season 18 but became co-chief residents in Season 19, Episode 18, “Ready to Run.”

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